The Patriots conduct research regarding a perpetual energy source. The research is extensive enough that Doktor speculates that they may have nearly successfully completed one prior to their destruction.
Hungary revises its citizenship laws. The new terms allow even those who have never resided in the country to become naturalized, provided they are a descendant of a Hungarian citizen and have knowledge of the Hungarian language.
Raiden infiltrates Area 51 in order to rescue Sunny, who is then left to Solid Snake and Otacon. He later drifts around the globe, ultimately ending up in Alaska where he learns scouting techniques from a tribal elder.
An American company plans to build an oil pipeline in an Eastern European country, and its pro-U.S. government approves PMC units to be stationed there to provide "security" during construction. Tensions rise between the government and the anti-U.S. opposition and a riot soon breaks out near the American embassy. U.S. PMC Raven Sword suppresses the riot, placing the government directly into Washington's front pocket, and opens up the country to a large-scale hunt down of the Paradise Lost Army resistance movement.
A Middle Eastern country suffers turmoil due to ethnic conflicts and lack of economic development. Many local militias join the PMCs to escape poverty, while the regime funds rival PMCs to enforce order, due to the fear of terrorism. The regime also hires British PMC Praying Mantis due to the group's involvement in the Iraq War.
In a South American country, a new government comes to power after ousting the old regime. Many soldiers of the state army are dissatisfied with the regime change, and leave to form an armed resistance movement against the new government. In response, the new regime requests that French PMC Pieuvre Armement aid them in fighting the rebels.
Solid Snake infiltrates Eastern Europe with the help of Meryl Silverburgh and Rat Patrol Team 01. By this time, the country's entire transportation network is shut down, with checkpoints everywhere. Snake meets with Paradise Lost leader Big Mama and discovers the location of Big Boss's presumed body. Liquid Ocelot captures the body, actually that of Solidus Snake, and uses it to access SOP before destroying it. Liquid locks down SOP during an attempted arrest by U.S. forces and escapes after killing dozens of American soldiers. Big Mama, a.k.a. EVA, dies from exposure to the new FOXDIE virus in Solid Snake.
Roy Campbell attends a UN-sanctioned ration swap meet. The swap meet reveals that the worst made rations in all of the UN are the ones in America.
Solid Snake makes it onto Outer Haven. He unknowingly uploads the FOXALIVE virus to JD, the Patriots' lead AI, destroying it and the entire Patriots AI system with it. The SOP system collapses with it.
Raiden returns to the battlefield as a military instructor and VIP bodyguard, after joining the PMSC Maverick Security Consulting, Inc., as a means of supporting Rose and Little John. One of his first assignments involves the European country of Montenegro, where he has to recover three Albanian mafiosos under the request of the Carabinieri. He and Maverick are later contracted with aiding in the reconstruction efforts and training of the military of an African nation that endured a costly civil war.
Samuel Rodrigues breaks into World Marshal Headquarters, intending to assassinate its leaders for sending others to die and keeping the status quo. He ends up fighting Senator Armstrong, losing his arm and joining Desperado Enforcement LLC.
Maverick's efforts in the rebuilding of an African country is successful. However, during a meeting between Raiden and the country's Prime Minister N'mani, Desperado ambushes the convoy and proceeds to kidnap N'mani, who is later killed by Sundowner. Samuel Rodrigues prevents Raiden from aiding N'mani, causing Raiden significant injuries that force him to adopt a new cyborg body. During Raiden's reconstructive surgery, Maverick secretly retrieves several corrupted data files from his severed left arm on a weekly basis, in order to avoid rival PMCs stumbling upon and exploiting them.
Three weeks later, Desperado, alongside Dolzaev, instigate a military coup against the parliamentary government of Abkhazia, transforming it into a military junta overnight, with Mistral being in direct command of the military coups' forces during this time. Khamsin is killed while attempting to stop the then-AWOL Blade Wolf, which had secretly been manipulated by Mistral. Raiden is deployed to Sukhumi, Abkhazia, after personally requesting that he actively participate in driving Desperado out, in order to restore the parliamentary government to its rightful owners. Desperado, anticipating this, dispatches a reluctant Blade Wolf to assassinate Raiden, but is defeated. Raiden then travels to the plant, where he duels and kills the Desperado captain Mistral. Dolzaev commits suicide by detonating a power pylon at the plant shortly thereafter.
The first batch of cyborg brain casings for the Sears Program are shipped to World Marshal HQ.
Raiden, alongside a rebuilt Blade Wolf, infiltrate a secret Desperado research facility in Guadalajara, Mexico, via a sewer entrance. They later rescue a Guyanese boy named George, who had escaped from the facility. During their infiltration of the base, Raiden discovers that Desperado have been kidnapping children in order to remove their brains and place them in cyborg bodies. After analysis of video files transmitted to Doktor, they realize that the children are to be made into child soldiers under the Sears Program, meant to replicate Solidus Snake's training methods during the Liberian Civil War. Raiden rescues the children and George, the latter of whom was recaptured by the lab before Maverick could get to him and escort him to safety.
Afterwards, Raiden travels to Denver to target World Marshal, Desperado's partner in the Sears Project, and a PMC that Senator Steven Armstrong has ties to. Because his actions would be considered illegal, he abruptly resigns from Maverick. He then makes his way to the headquarters, also killing Monsoon, after having his Jack the Ripper persona re-emerge after an emotionally breaking lecture from Sam. He confronts and kills Sundowner on the building's rooftop, and deduces that Armstong's Operation Tecumseh will involve creating a false flag operation, causing Raiden to suspect that it involved assassinating President Hamilton and then making it seem as though he died as a result of Pakistani rebels at the Shabhazabad military base. Knowing they'll need Mach 23 to reach the base in time, Raiden travels to Solis, after ensuring that Doktor's flight path for the brain casings was clear. He then steals a motorbike to escape from Denver, and in a final duel with Sam, kills him.
Upon arrival at Solis, Raiden is sent via a spacecraft designed by Sunny to Pakistan in close proximity to the base. He then infiltrates the base and ends up fighting Metal Gear EXCELSUS and a nanomachine-enhanced Armstrong, learning that Hamilton had been redirected to America due to the base being overrun by cyborgs. He ultimately kills Armstrong.
President Hamilton reattempts negotiations in Pakistan, with the promise of a joint effort against terrorism. Despite Armstrong's death, the use of PMCs continues to rise. Raiden resigns permanently from Maverick, deciding to fight his own war.
Doktor manages to develop a cyborg job center, giving the children who became cyborgs due to World Marshal's machinations, a job outside of conflict, as well as ensuring they will at least get an education.
A more precise date for the events of Metal Gear Solid 4: Guns of the Patriots may be implied by a checkboard that Sunny uses to record the chickens' egg laying, on board the Nomad. This checkboard, visible during each briefing, remains unchanged throughout the game, and shows March having less marks than January or February, and April and May having no marks.
^ abcdefghijklmnopqrMetal Gear Rising: Revengeance, Kojima Productions/Platinum Games (2013).
^Metal Gear Solid 4 Database, Kojima Productions (2008).
^Metal Gear Solid V: The Phantom Pain, Kojima Productions (2015).
^ abcdefMetal Gear Rising: Revengeance, Kojima Productions/PlatinumGames (2013). News reporter: President Hamilton returns from Pakistan today, completing his first visit to the country since the failed assassination attempt at Shabhazabad last May.