Big Boss may refer to:
- Big Boss, renowned special forces operative and founder of FOXHOUND and Outer Heaven;
- Venom Snake, Big Boss's phantom and commander of Diamond Dogs and the Outer Heaven fortress;
- Big Boss (Operation 747), commander of FOXHOUND, Outer Heaven and another enemy base;
- Big Boss (Gindra), commander of FOXHOUND and Outer Heaven in Gindra.
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