Boss may refer to:
- The title bestowed upon individuals who displayed extraordinary fighting capabilities and services to their country.
- The Boss, originally known as The Joy, the mother of U.S. Special Forces, the founder and leader of the Cobra Unit.
- Big Boss, originally known as Naked Snake, the renowned special forces operative and mercenary commander.
- Venom Snake, the body double for Big Boss during the 1980s.
- Liquid Snake, the leader of FOXHOUND during the Shadow Moses Incident and the brother of Solid Snake.
- The term used for major enemies in video games.
- The coffee company that collaborated with Konami to promote Metal Gear Solid V: The Phantom Pain.
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