Mother Base may refer to:
- The old OTEC plant in the Caribbean sea that acted as the Militaires Sans Frontières' base of operations in 1974-1975.
- The offshore plant near the Seychelles Archipelago that acted as the base of operations for the Diamond Dogs during the 1980s.
- four bonus characters that when unlocked via certain pre-orders acted as staff members for the aforementioned offshore plant.
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