A tranquilizer gun (or tranq gun) is a handheld firearm whose ammunition is non-lethal, and used to knock enemies unconscious. Tranquilizer guns in the Metal Gear Solid games include:

Tranquilizer guns are extremely effective in that they are a suppressed, non-lethal way, to temporarily eliminate an enemy threat. Metal Gear Solid 2-4, Portable Ops, and Peace Walker all have a tranquilizer guns in their game. It has been confirmed through released gameplay that Metal Gear Solid V: Ground Zeroes and The Phantom Pain will have a tranquilzer gun. It is unknown if it has customizable attachments like other, more lethal weapons.

Behind the scenes

In Portable Ops and Portable Ops Plus, the ammunition containers for the Mk22 and Mosin Nagant (9mm T and 7.62mm T, respectively) display a star and crescent, presumably to symbolize nighttime.

In Metal Gear Solid: HD Collection, hitting 100 soldiers with tranquilizers in Metal Gear Solid 2 will result in the unlocking of the achievement/trophy "Don't Taze Me, Bro."

On November 8, 2016, an update was issued that allowed for the development of the Anti-Tranq Agent. It is available under the security devices tab. It worked from grades 4 to 6.

"Anti-tranquilization agent.
Stops tranquilizers up to a certain grade from circulating through the body over time.
―Anti-Tranq Agent description in Metal Gear Solid V: The Phantom Pain

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